The Toxicity of Methylisothiazolinone

Methylisothiazolinone and its closely related an anlog, chloromethylisothiazolinone or CMIT, affect the ability of young or developing neurons to grow processes in tissue culture.
The toxic actions of Methylisothiazolinone on developing neurons occurs at much lower concentrations than those inducing lethal injury (1-3 micromolar).
The increase is primarily caused by increasing consumer exposure to MI from cosmetic products; exposures to MI in household products, paints and in the occupational setting also need to be considered.
The delay in re-evaluation of the safety of MI in cosmetic products is of concern to the SCCS; it has adversely affected consumer safety.
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